8 Best Mouse Poison on the Market

Best Choice
Farnam Just One Bite II Bait Chunks Poison
Farnam Just One Bite II Bait Chunks
  • Kills in just one go
  • For all weather conditions
  • Affordable price
Best Value
Tomcat Bait Chunx Pail
Tomcat Rodent Bait Chunx Pail
  • Waterproof Pellets
  • Can kill Norway Rats
  • Cheap
Amazon’s Choice
Motomco Tomcat Rat and Mouse Bait Pellet
Motomco Tomcat Rat and Mouse Bait Pellet
  • Can kill immediately
  • Pellets don’t dry out
  • Made in USA

While killing mice is not the most humane way to treat an infection, it is one of the most effective methods. A good mouse poison will ensure that your home or car has been sufficiently protected and you don’t need to deal with the pest any longer. It is one of the fastest methods to get rid of mice infestations around the home.

Choosing these rats and mice products are not that easy and many people buy the first product they see without doing the right research. In this article, I take all of my knowledge and add a little bit of research to help you find the ideal poison that is available on the market today.

8 Best Mouse Poison Effectiveness Review

**WARNING** Always look carefully at the labels and follow the instructions to the letter to ensure you and your environment does remain safe. These poisons are extremely toxic and can even be fatal to humans, children and pets.

The best mouse poisons can be hard to come by. However, my research has led me to find some of the top options on the market today.

Here are some of the best mouse poisons that are available on the market today:

Farnam Just One Bite II Bait Chunks

Active Ingredient: Bromadiolone

Farnam Just One Bite II Bait ChunksUsing the Farnam Just One Bite II Bait Chunks is extremely effective if you want to kill mice immediately. As the name states, it can kill mice and rats, as well as other rodents with just one bite. The poison contains the lethal active ingredient of Bromadiolone, making it ideal for killing large infestations of rodents without using too much poison.

While you can potentially use it in your home, it is best reserved for industrial areas with no children and pets around. Unfortunately, this poison will kill almost anything that eats it in just one bite, making it an effective mica and rat poison for all areas.


  • It can kill in just one go
  • Large bulk buy
  • Ideal for all weather conditions
  • Kills Norway and roof rats
  • You need a bait stations
  • Dangerous for all animals

Tomcat Bait Chunx Pail

Active Ingredient: Bromethalin

Tomcat Bait Chunx PailAnother effective killing tool to have in your arsenal is the Tomcat Bait Chunx Pail. These bait blocks have the active ingredient Bromethalin that can effectively wipe out most rats and mice in a single go. They also work well again those anticoagulant resistant Norway rats. However, it will kill most mice in your house with just one serving.

Since the rodents will stop feeding after the first dose, you will have more and more bait to kill even larger quantities of mice without spending too much. The pellets are waterproof and they won’t succumb to mold, but I do recommend using them in some areas that do not have a lot of moisture.

  • Can kill Norway Rats
  • Waterproof Pellets
  • Can be used for a long time
  • Large container available
  • Rats may avoid it
  • Not ideal for pets

Motomco Tomcat Rat and Mouse Bait Pellet

Active Ingredient: Diphacinone

Motomco Tomcat Rat and Mouse Bait PelletOne of the easiest ways to start setting up the poison will be to use the Motomco Tomcat Bait Pellets. These pellets are already good to go and you need to place them where you feel they will have the most effect. Since they are made from 2nd Generation Anticoagulant, they should work extremely effective and kill mice in just a couple of days.

Unfortunately, the bait is also really tough to handle and can kill many of your pets on the first go as well. You will need to place it somewhere out of the reach of pets and your children. The poison is also quite expensive but will last really long. It is mostly recommended for farms and areas away from human activity.

  • Can kill immediately
  • Pellets don’t dry out
  • Pellets are easy and simple to use
  • Extremely poisonous
  • It can kill your pets
  • A little expensive

D-Con Ready Mix Rat and Mouse Killer

Active Ingredient: Brodifacoum

D-Con Ready Mix Rat and Mouse KillerOne of the best ready mix products for getting rid of mouse is the D-Con Ready Mix Rat and Mouse Killer. It contains 8 bait trays and a combined with of 3-pounds of poison that will effectively take out most rats and mice in only 5 days when a lethal dosage has been consumed. However, it can also take longer for many larger rodents. This poison can be used both indoors and outdoors.

One of the best features is the fact that this is basically a bait stations that will continuously draw mice to the area and can be used to divert them away from other areas. While it can be set up with little to no effort, you should keep in mind that the EPA has gone on record to cancel a couple of D-Con products for killing rodents.

  • Works as a bait station
  • Not that fatal to pets
  • Can kill in one feeding
  • Easy and simple to use
  • Kills other animals like squirrels and chipmunks as well

Contrac Blox Rodent Control Rodenticide

Active Ingredient: Bromadiolone

Bell Labs Contrac Blox Rodent Control RodenticideBeing available for users in an 18-pound supply for one year, the Contrac Blox Rodent Control Rodenticide is an effective block bait. Since it becomes hard when in conditions with a lot of moisture, it can effectively be placed over holes and other areas to keep the mice out. The poison has been formulated with foods and can kill most mice and rats with only one go.

Since it is extremely poisonous for smaller animals, it might not kill your pets instantly. Generally, the secondary poisoning over a long time will kill the pets. It can be used almost everywhere and should be kept out of the reach of pets if possible. I recommend it for areas that have a large infestation of rats to deal with.

  • Effectively kills most rodents
  • Can be used for up to 2 years
  • The poison won’t instantly kill pets
  • Can kill with one single feed
  • The poisonous blocks can become a little moldy

NEOGEN RODENTICIDE Ramik Rat and Mouse Bait Pail

Active Ingredient: Diphacinone

NEOGEN RODENTICIDE 45-Pack Ramik Rat and Mouse Bait Pail

Available in a large pack with nuggets that are impervious to weather conditions, the NEOGEN RODENTICIDE Ramik Pail is one of the most effective killers. The fish flavor gives it a strong smell to attract rats and it can basically kill rats and other rodents of all sizes in virtually every area around the house.

With Diphacinone as the main ingredient, this is one effective poison and it can kill small pets like dogs and cats as well. The 2nd Generation poison will kill with just one feeding and since no wax has been used, it is impervious to all weather conditions.

  • Suitable for rodents of all sizes
  • Cheap
  • Impervious to weather conditions
  • Has a strong smell to attract rats
  • Lasts a long time
  • Kills pets with just one feed

First Strike Soft Bait Rodenticide Poison

Active Ingredient: Difethialone

First Strike Soft Bait Rodenticide PoisonThe First Strike Soft Bait Rodenticide Poison is one of the best options that rodents accept and this makes it one of the fastest killers on this list. It features a soft bait with a smell that will attract rodents, but kill them with just one bite. Difethialone is a 2nd Generation poison that has been designed to kill many mice fast.

While you might need a bait station, the pouch design of the poison means it can be placed almost anywhere. This is a new concept that has been designed to ensure that mice do actively find the poison at a faster rate. Since it is recommended for industrial use, you should keep it away from pets and other animals.

  • Multifunctional pouch design
  • Attracts mice fast
  • Easy to set up
  • Kills instantly
  • Dangerous for other pets
  • Needs a bait station

JT Eaton 709-AP Bait Block Rodenticide Anticoagulant Bait

Active Ingredient: Diphacinone

JT Eaton 709-AP Bait Block Rodenticide Anticoagulant BaitLast but certainly not least, I have the JT Eaton 709-AP Bait Block Rodenticide Anticoagulant Bait. Formulated with an apple scent, it does not have such a bad smell and these bait blocks can be placed almost anywhere. They are weatherproof and the active ingredient Diphacinone should kill in a matter of days, if not instantly.

It is an industrial killer and available in a large bulk container that makes it much easier to place it in various areas. Unfortunately, you should keep it away from other animals and it can be really fatal for your pets.


  • Kills in one feed
  • Weatherproof design
  • Works with bait stations
  • Long lasting
  • Pretty cheap
  • Dangerous to other animals

Types of Poison: How Does Mouse Poison Work

There are numerous types of poisons you will come across and they all have an innate ability to get the job done. These different poisons can be harmful to you and the close environment around us. However, the list of most effective poisons are here and you can see how they could affect you and your environment:


One of the most lethal poisons you can give mice is the anticoagulant, and this has been split into the 1st and 2nd generation poisons. Depending on, it will take longer or shorter to kill the rodents, with 2nd generation poisons acting much faster and potentially being lethal in just a couple of days. The 1st generation can also act as a deterrent but takes up to 2 weeks to kill the mice.

The anticoagulants work by blocking off the vitamin K cycle and this allows blood clotting and other factors to come into play. It can kill the mice in just a couple of weeks from damage to the tiny blood vessels and cause internal bleeding.

These poisons can also be harmful to human beings when they are ingested and this is due to the close proximity of the rat’s digestive system to that of a human. However, Vitamin K has been used as an antidote to ensure that it does not really affect humans or to cure them.

Metal Phosphides

Metal Phosphides are also a commonly used method of killing mice and this takes the different metal elements to stack them inside a tablet. It is fed to the mice with the help of other foods and death can occur within 1 -3 days of the conception at lethal doses.

It is commonly used in areas where mice or rodents have become immune to 2nd Generation Anticoagulants and it is far cheaper. The process will allow the acid from the digestive system to interact with the Phosphides and this can lead to the production of a lethal Phosphide gas that will eventually kill the mice. Here are some of the common Metal Phosphides:

  • Calcium Phosphide
  • Aluminum Phosphide
  • Magnesium Phosphide
  • Zinc Phosphide (Only recommended to be used as bait)

Other Options

While these are the 2 most common methods, there are also a couple of other poisons that can be used for killing mice. Not all of them are humane and the results will vary depending on the area and the severity of infestations. These poisons include gasses like White Phosphorus, but it might also be worth looking into and can be harmful to the human body.

As mentioned, many of these need to be handled with care and cause a lot of concern for the user and the environment. Many tests have shown that they can actually affect the other wildlife in the area and this does include some of the household pets. The time for fatality will differ depending on the used product.

How Long Does It Take to Work 1st vs 2nd Generation?

No poison aside from your rifle or weapon will work as effectively as many people would like. The poison will vary depending on the dose and the type. While Anticoagulants are the most common, it is also the poison that I have assessed to see how long it will take to be effective on mice and infestations:

1st Generation

These poisons can take a little longer than most and occasionally need some sort of bait to keep the rodents from coming back. Depending on the poison itself and the dosage, it can take anywhere from 1 to 2 weeks for a fatality to be achieved. However, a higher dose should speed up the process more significantly.

2nd Generation

The 2nd Generation Anticoagulant is far more potent and can be administered in higher dosages. This is far more fatal than any of the other dosages and can kill the mouse in just a couple of minutes effectively to ensure they are dead. However, the 2nd Generation Anticoagulants are also extremely potent and can have an effect on the environment around you.

Single Feed and Multi Feed Poison – What’s the Difference?

The difference between these 2 poisons is not as apparent as one might think.

Single feed poisons rarely have good results and they can’t effectively allow you to achieve your results. However, they are extremely potent and should knock out the mice in just a matter of days.

Additionally, you will find the multi-feed poisons and these take a little longer than most to work. These poisons are not as effective at killing the mice off the bat and will require a sustained feeding system. They are also better for the environment if the poisonous area is monitored.

Usage Precautions

WARNING: Precautions are one of the most important steps that any homeowner can take to ensure they are safe.

Not only do you need to protect your pets and other animals from the poison, but yourself as well.

One of the best areas to start is the warning label on the poison. The warning label will inform you of all the hazardous issues and keep you safe at the same time. Here is a list of common equipment you can have on hand when setting up mouse poison:

  • Gloves to keep the hands protected
  • A head mask to keep yourself from ingesting the poison
  • Industrial soap to wash the poison away
  • Closed containers for only rodents to reach
  • Detergent to ensure that all the equipment you used can be washed, including clothes

Another safety precaution is to simply throw away all the equipment you have used when setting up the mouse poison. This is one of the safest methods to ensure that you don’t have any attached to yourself. A good shower is also recommended.

Buying Guide: How to Choose the Best Mouse Poison

To get yourself the top mouse poisons, there are a couple of features you need to know about to ensure you get results. These features are more like considerations rather than features but have an effect on the type of mouse poison you choose.

Here are a few things to consider before buying mouse poison:


The first thing that any person will look for in rat poisons is the ingredients that have been used to make them. Thallium, Barium, Ammonia, and Arsenic ingredients are some of the most common. The poison you choose might have a combination of these ingredients or potentially target all of them at the same time in lower doses.

Metal Phosphides and vitamin-based poisons take a little longer to work than most others. However, arsenic and thallium can potentially be hazardous to all living things, including humans. It will all come down to the pets you have around and your intended goal.

The Form

Unfortunately, you won’t have the raw ingredient to kill mice and they generally have a bad smell that won’t attract any mice. It is important to find the right form you will need. Here is a small breakdown of the different forms that mouse poison can come in:

  • Pellets: Pellets are extremely common and used in fields or on farms to eliminate mice. However, they can also be harmful to pets and other forms of life that find them.
  • Block Baits: Block baits are fairly common to use in urban areas and they have a wax-like design. This makes them effective to be placed in mousetraps and on the wall.
  • Liquid Toxins: While effective, liquid toxins are some of the last options you would like to go after. They can poison a water supply but will work effectively if you have a mouse or rat infestation near an unused water supply.

All of these forms are fairly effective and the user will need to decide which one will fork the best for the issue they have. Almost every ingredient can be formulated to be placed in any of these specific forms for use.


The quantity you choose will depend on the infestation and the number of mice that need to be killed. This will vary depending on the rodent infestation and the type of rodents. While I cannot specify the right quantity, you need to keep the toxicity of the poison in mind as well to ensure that you do kill them effectively.


I did a small section on the safety and the precautions, but you need to make sure that the poison can be handled by yourself without putting you or anyone at risk. Fortunately, most poisons will have all the needed safety equipment included that should be used. It is important to follow the label and the instructions carefully.

Additional Things To Consider

The above-mentioned features are the most important, but before you buy, you also need to consider another few important things.

Here are some of the important things that you will need to consider if you want the best effect:

  • Size of the area: The size of the area is important to show you how much poison you will need to make for the best results
  • Impacts on the environment: Since your primary goal is to get rid of rodents, you might need to look at how it can affect the environment. The goal is to kill rodents and not any of your pets or other animals.
  • Dosage: If you don’t want to spend many hours or days poisoning the mice, the dosage is fairly important to consider. If you need to get rid of them fast, you might need to choose something that is more toxic.

What to Do if Mouse Poison Doesn’t Work

Mouse poison should be really effective, but it does not always work. Often times, mice can become immune to the poison and it can have an effect on the environment. Not all mice will go for the bait and this will force you to think outside of the box.

Here are a few other methods that you can use to get rid of mouse:

  1. Mouse traps: Mouse traps have been around for ages and if your poison does not work you might consider it as a way to get rid of the infestation
  2. Exterminator: While it can be a little more expensive, an exterminator will have all the tools to get the job done faster.
  3. Other repellents: Various other repellents can be found to simply keep the mice away from your area. You should also consider cleaning up and making sure they have no food around.

Frequently Asked Questions

Do Sticky Mouse Traps Have Poison?

It will depend on the type of mouse trap that you have. While many can have mouse poison, you have a few that do not have it. Generally, the mouse will get stuck and die from hypothermia, which might not be humane either.

Will Mouse Poison Kill Rats?

Most poisons are considered to be rodent poisons and this will allow them to kill any rodent. However, the active ingredient of mouse poisons can make them effective for rats. If they can kill your pets, they will definitely get rid of rats.

Does Mouse Poison Kill Cats?

Much similar to the answer above, it will all depend on the poison and the type of active ingredient that has been used inside. However, most mouse poisons that I have on this list will definitely kill your pets and cats.

Can a Dog Die From Eating a Poisoned Mouse?

Dogs have a larger body and a stronger immune system, but they will eventually succumb and die from the poison. The poison might not kill them immediately when small quantities have been ingested, but depending on the mouse they have eaten, they might fall prey to the same fate as the mouse if not treated.

Pet Safe Mouse Poison?

Unfortunately, there are no active ingredients in mouse poisons that are safe for pets. You might need to consider doing a mouse trap of any other form of repellent instead of using mouse poison.


With so many different mouse poisons available, it can be really hard to find the right one. However, this article should help you to ensure you get the best poison for your needs and situation. Let me know in the comment section, what you think and if I might have missed any other great ingredients or mouse poisons.

**WARNING** The above-mentioned products are dangerous and should be handled with care. It is important to look at the label and follow the instructions.